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SECTION 1 of 4

Highlights for sildenafil

Oral tablet

1

Sildenafil is used to treat pulmonary arterial hypertension (PAH). This condition causes high blood pressure in your lungs. Sildenafil slows down the worsening of your illness. It also makes you more able to exercise.

2

This drug comes in the form of a tablet and suspension (liquid) you take by mouth. It also comes as an injection that’s only given by a doctor.

3

Sildenafil is available as a brand-name drug called Revatio. It’s also available as a generic drug.

4

The more common side effects of this drug include nosebleeds, headaches, upset stomach, or flushing (reddening and warming of the face). They also include trouble sleeping, fever, or erections that last longer than normal.

5

In some cases, sildenafil can cause serious side effects. These can include sudden vision loss, hearing loss, or an erection lasting more than 4 hours.

IMPORTANT INFORMATION

  • Priapism

    Priapism (an erection that won’t go away) See Details

  • vision loss

    Sudden vision loss See Details

  • hearing loss

    Sudden hearing loss See Details

  • Not for use in children

    Not for use in children See Details

Why it's used

This drug is used to treat pulmonary arterial hypertension (PAH) in adults. With this condition, the blood pressure in your lungs is too high. Your heart has to work very hard to pump blood into your lungs. 

This drug slows down how fast your illness worsens. It also makes you more able to exercise.

How it works

This drug belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by relaxing the muscles and opening up the blood vessels in your lungs. This decreases the blood pressure in your lungs.

SECTION 2 of 4

sildenafil Side Effects

Oral tablet

More Common Side Effects

The more common side effects of sildenafil can include:

  • nosebleeds

  • headaches

  • upset stomach

  • flushing (reddening and warming of the face)

  • trouble sleeping

  • fever

  • an erection that lasts longer than normal

  • respiratory infection

  • nausea

  • vomiting

  • bronchitis

  • pharyngitis (sore throat)

  • runny nose

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Low blood pressure. Symptoms can include:

    • blurry vision
    • confusion
    • dizziness
    • fainting
    • lightheadedness
    • nausea or vomiting
    • sleepiness
    • weakness
  • Increased shortness of breath or trouble breathing

  • Priapism (an erection that won’t go away). Symptoms can include:

    • an erection that lasts more than 4 hours
  • Vision problems. Symptoms can include:

    • sudden vision loss in one or both eyes
  • Hearing problems. Symptoms can include:

    • sudden hearing loss
    • tinnitus (ringing in your ears)
    • dizziness
  • Heart problems, such as heart attack, stroke, or irregular heart rate. Symptoms can include:

    • chest pain
    • shortness of breath
    • dizziness
    • trouble speaking
    • confusion
    • nausea or vomiting
    • feeling lightheaded

Pharmacist's Advice

Mary Lynn Moody, RPh, BSPharm

Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Sildenafil doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

SECTION 3 of 4

sildenafil May Interact with Other Medications

Oral tablet

Sildenafil can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. 

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Alcohol interaction

The use of drinks that contain alcohol raises your risk of low blood pressure from this drug. If you drink alcohol, talk to your doctor. You may need to have your blood pressure monitored.

Medications that might interact with this drug

Drugs you should not use with sildenafil

Do not take these drugs with sildenafil. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Nitrates, such as isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin. 
    • Taking these drugs with sildenafil can cause your blood pressure to drop suddenly to an unsafe level. 
  • Guanylate cyclase stimulators, such as riociguat. 
    • Taking these drugs with sildenafil can cause your blood pressure to drop suddenly to an unsafe level.

Interactions that increase your risk of side effects

Side effects from sildenafil: Taking sildenafil with certain medications raises your risk of side effects from sildenafil. This is because the amount of sildenafil in your body is increased. Examples of these drugs include: 

  • Human immunodeficiency virus (HIV) drugs, such as ritonavir, indinavir, saquinavir, or atazanavir. 
    • Increased side effects can include low blood pressure, dizziness, or vision problems. They can also include erections that last longer than normal.
  • Certain antibiotics, such as clarithromycin, telithromycin, or erythromycin.
    • Increased side effects can include low blood pressure, dizziness, or vision problems. They can also include erections that last longer than normal.
  • Certain antifungals, such as ketoconazole or itraconazole.
    • Increased side effects can include low blood pressure, dizziness, or vision problems. They can also include erections that last longer than normal.

Side effects from other drugs: Taking sildenafil with certain medications raises your risk of side effects from these drugs. Examples of these drugs include:

  • Alpha-blockers, such as terazosin, tamsulosin, doxazosin, alfuzosin, or silodosin.
    • Increased side effects can include a drop in blood pressure, or fainting. 
  • Blood pressure drugs, such as amlodipine.
    • Increased side effects can include blood pressure that’s too low.
  • Drugs for erectile dysfunction, such as avanafil, tadalafil, or vardenafil.
    • Increased side effects can include low blood pressure or erections that last longer than normal.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Pulmonary arterial hypertension (PAH)

Brand: Revatio

Form: Oral tablet

Strengths: 20 mg

Form: Oral suspension

Strengths: 10 mg/mL

Generic: sildenafil

Form: Oral tablet

Strengths: 20 mg

Adult dosage (ages 18–64 years)

  • Typical dosage: 5 or 20 mg, taken 3 times per day.
  • Maximum dosage: 20 mg, taken 3 times per day.

Child dosage (ages 0–17 years)

This drug shouldn’t be used in people younger than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys, liver, or heart of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dose of sildenafil. This can help keep levels of this drug from building up in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

Pharmacist's Advice

Mary Lynn Moody, RPh, BSPharm

Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your condition won’t improve, and may get worse. Also, you won’t be able to exercise. 

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • low blood pressure
  • fainting
  • dizziness
  • vision problems
  • hearing problems
  • upset stomach
  • chest pain

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

You’ll be able to exercise more easily. Your doctor will also check you to decide if this drug is working.

This drug is used for long-term treatment.


Source: http://www.healthline.com/drugs/sildenafil/oral-tablet


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