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Additional Quest Articles Article 1 of 289 The Pendulum Begins to Swing Back: USPSTF Backs Away from PSA Screening Ban The mission of the U.S. Preventive Services Task Force (USPSTF) is to evaluate the benefits and harms of health services for primary care physicians. On April 11, 2017, the USPSTF issued a new draft recommendation that no longer deprives men of PSA s...

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Back to top Article 2 of 289 In the Wake of the Previous USPSTF Guidelines Recent research found declines in the numbers of U.S. men who were getting screened, diagnosed and therefore treated for prostate cancer in the wake of the 2008 and 2011 USPSTF recommendations against PSA testing. Fewer men were being screened for pr...

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Back to top Article 3 of 289 Regular Aspirin Use Could Lower Risk of Lethal Prostate Cancer A new analysis found that patients who took aspirin regularly had a lower risk of developing lethal prostate cancer. Researchers defined regular aspirin usage as more than 3 tablets per week for at least 1 year, and lethal prostate cancer was defi...

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Back to top Article 4 of 289 Trajectory of Body Mass Index (BMI) and Prostate Cancer Risk Previous research suggests that obesity in adulthood is associated with an increased risk of clinically significant prostate cancer. A new study examined the trajectory of BMI beginning at age 20 to determine if being overweight at a younger age affe...

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Back to top Article 5 of 289 Father Medard Laz's Journey of Healing, Hope and Help Thirteen years ago, Father Medard Laz survived prostate cancer. After his successful surgery, he returned to his life in Florida and set his sights on spreading help—and hope—in Haiti. Father Laz had always been aware of his family’s history of pr...

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Back to top Article 6 of 289 5-ALPHA-REDUCTASE INHIBITORS Research Looks Further into Side Effects 5-alpha-reductase inhibitors are drugs such as finasteride (Propecia and Proscar) or dutasteride (Jalyn), which are used to treat hair loss and prostate enlargement. The medications have been under recent scrutiny for claims of adverse psychiatric si...

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Back to top Article 7 of 289 Prostate Health Index (phi) Predicts Aggressive Prostate Cancer A study published in BJU International examined the use of the Prostate Health Index (phi) test as a tool in assessing risk for aggressive prostate cancer, defined as a Gleason score of 7 or greater upon biopsy. The men in the study all had PSA le...

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Back to top Article 8 of 289 Midlife Baseline PSA Predicts Lethal Prostate Cancer A case-control study found that a midlife PSA above the median strongly predicted future lethal prostate cancer. The authors suggested that risk-stratified screening on the basis of midlife PSA should be considered for men ages 45 to 59 years. The...

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Back to top Article 9 of 289 The PROMIS Trial: Using MRI to Avoid Unnecessary Biopsies New results from the UK-led PROMIS trial found that multiparametric MRI scans—advanced technology in scans—could improve diagnostic accuracy and prevent unnecessary biopsies for men with suspected prostate cancer. Typically, men with elevated PSAs...

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Back to top Article 10 of 289 Guidelines Urge Treating Older Men According to Their Health Status, Not Age New guidelines from the International Society of Geriatric Oncology said that prostate cancer patients older than 70 years should be treated based on their individual health status, not on their age. The task force also said that elderly patients who...

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Back to top Article 11 of 289 Using PSA to Detect Men at High Risk for Death After Treatment Two-thirds of all prostate cancer deaths in the U.S. occur in men with localized disease who developed metastatic cancer. New research looked at PSA levels in these men after treatment to determine if there was a way to predict who was more likely to...

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Back to top Article 12 of 289 Treating Prostate Cancer Recurrence: Adding Antiandrogen Therapy to Radiation Improves Survival A long-term clinical trial at Harvard University evaluated the efficacy of adding antiandrogen therapy (bicalutamide) to radiation therapy for men with biochemical prostate cancer recurrence. Arising PSA following a prostatectomy is called biochem...

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Back to top Article 13 of 289 The Family History Effect: An Increase in Probability of Prostate Cancer A large analysis of brothers in the Prostate Cancer data Base Sweden (PCBaSe) showed that men with a family history of prostate cancer were more likely to get clinically significant prostate cancer. The study included 51,897 brothers of 32,807 men...

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Back to top Article 14 of 289 ADT and Prostate Cancer: Dementia Risk, Fatique and Exercise Studies Continue to Examine Androgen-Deprivation Therapy (ADT) and Dementia Risk and Exercise Can Improve Fatigue for Patients on Androgen Deprivation Therapy...

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Back to top Article 15 of 289 New Statistics on Prostate Cancer in the U.S. 2017 American Cancer Society Statistics Each year, the American Cancer Society (ACS) releases new data on cancer rates in the U.S. and Reduction of Cancer Mortality Rates in the U.S....

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Back to top Article 16 of 289 Reflections at the Year's End At this time of year, it is natural to reflect on my good fortune in having support from my contributors and friends, and I want to send my thanks and best wishes for a happy holiday season and good health in the New Year. I also want to bring you up...

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Back to top Article 17 of 289 The Protect Trial: Comparing Surgery, Radiation and Surveillance for Localized Prostate Cancer at 10 Years Follow-Up The latest results from the ProtecT trial, a large UK-based randomized study, compared radical prostatectomy, external beam radiation therapy, and active monitoring for patients who had PSA testing and were diagnosed with localized prostate cancer. T...

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Back to top Article 18 of 289 Understanding the Prostate Health Index (phi): A More Specific Test to Screen for Prostate Cancer The prostate-specific antigen (PSA) test is widely used for prostate cancer screening. However, PSA has limited specificity for prostate cancer. The Prostate Health Index (phi) is nearly 3 times more accurate in detecting prostate cancer than the fre...

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Back to top Article 19 of 289 2016 NCCN Guidelines for Prostate Cancer Early Detection The National Comprehensive Cancer Network (NCCN) annually updates its guidelines for the early detection of prostate cancer. These guidelines are important because many health insurance companies determine coverage based on NCCN panel recommendations...

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Back to top Article 20 of 289 Genetic Changes and Cancer Cancer is a genetic disease- that is, cancer is caused by certain changes to genes that control the way our cells function, especially how they grow and divide. These changes include mutations in the DNA that makes up our genes. Genetic changes th...

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Back to top Article 21 of 289 Surviving Prostate Cancer through Early Diagnosis: A Patient’s Story I have always taken control of my health and have been very active and proactive in my approach to my own health and well-being. I have always had routine physicals and monitored and documented my blood work results. I had my first PSA test when I...

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Back to top Article 22 of 289 Saturated Fat Linked to Aggressive Prostate Cancer Saturated fat is commonly found in foods such as fatty beef and cheese. According to a new study, eating a diet high in saturated fat may increase the chances of having aggressive prostate cancer. The study used data on 1,854 men diagnosed with pr...

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Back to top Article 23 of 289 Research Assesses the Effects of the USPSTF Recommendation The advent of PSA testing in the 1990s led to an increase in the number of men diagnosed with prostate cancer. However, concerns about over-screening and overdiagnosis led professional guidelines, such as those of the U.S. Preventive Services Task Fo...

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Back to top Article 24 of 289 The Gцteborg Trial: Long-Term Results of Active Surveillance Raise Questions The Gцteborg Prostate Cancer Screening Trial is a randomized, population-based European study. Recent results assessed the long-term safety of active surveillance (AS) for men with prostate cancer detected through a screening program. The study in...

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